Acinar origin of CFTR-dependent airway submucosal gland fluid secretion

JV Wu, ME Krouse, JJ Wine - American Journal of …, 2007 - journals.physiology.org
… with a lack of fluid secretion or absorption by the ductal epithelium. We conclude that
CFTR-dependent gland fluid secretion originates in the serous acini. The failure to observe either …

Submucosal glands and airway defense

JJ Wine, NS Joo - Proceedings of the American Thoracic Society, 2004 - atsjournals.org
… CF airway disease, and we propose that an important source of … fluid secretion from
serous cells of submucosal glands. With … acini secrete a Cl – /HCO 3 – -rich fluid by CFTR-dependent

Ca2+ signaling and fluid secretion by secretory cells of the airway epithelium

RJ Lee, JK Foskett - Cell calcium, 2014 - Elsevier
… in fluid secretion by airway exocrine secretory cells. Airway submucosal gland serous acinar
… In this review, the anatomical origin of the gland will be noted (ie, animal and airway location…

Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process

JY Choi, M Khansaheb, NS Joo… - The Journal of …, 2009 - Am Soc Clin Investig
… ACh can still stimulate secretion from CF airway glands, fluid secretion stimulated by VIP is
… ) was superfused over the glands, we observed rapid shrinkage of acinar serous cells by 15…

CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands

ST Ballard, L Trout, Z Bebök… - American Journal of …, 1999 - journals.physiology.org
… The authors of these studies reasoned that this secreted liquid likely originated from
submucosal glands, although they could not rule out significant contributions from nonglandular …

Role of CFTR in epithelial physiology

V Saint-Criq, MA Gray - Cellular and Molecular Life Sciences, 2017 - Springer
… as by fluid secretion arising from submucosal glands. Indeed, … was CFTR-dependent but
that although fluid secretion was … in acinar cells [114, 115], and is essential for electrolyte and …

Mechanisms of Ca2+-stimulated fluid secretion by porcine bronchial submucosal gland serous acinar cells

RJ Lee, JK Foskett - American Journal of Physiology-Lung …, 2010 - journals.physiology.org
Mechanisms of Ca2+-stimulated fluid secretion by porcine bronchial submucosal gland
serous acinar cells | American Journal of Physiology-Lung Cellular and Molecular Physiology …

Role of CFTR in airway disease

JM Pilewski, RA Frizzell - Physiological reviews, 1999 - journals.physiology.org
… The origin of most nonmucin submucosal gland secretory … modification of airway fluids by
CFTR-dependent processes … of an isosmotic primary secretion in submucosal gland acini and …

Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands

JP Ianowski, JY Choi, JJ Wine… - Pflügers Archiv-European …, 2008 - Springer
… /6/1/129 or Balb/c genetic background, whereas infection-induced inflammation develops
in a … Elevation of Ca 2+ and cAMP in acinar cells by substance P would provide the simplest …

Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease

AS Verkman, Y Song… - American Journal of …, 2003 - journals.physiology.org
… Defective CFTR-dependent bicarbonate transport in CF is … cell cultures of acinar submucosal
gland cells give secretory short-… The origins of ASL remain poorly understood in terms of the …